Progesterone cream is a topical preparation that contains progesterone, a hormone that plays an important role in regulating menstrual cycles and maintaining pregnancy. The cream is applied directly to the skin, where it can be absorbed into the bloodstream and have various effects on the body depending on the dosage and individual needs. Progesterone cream is often used as a natural treatment for symptoms of hormonal imbalance such as premenstrual syndrome (PMS), menopause, or perimenopause. It can also be used to support fertility in women trying to conceive. However, it's important to consult with a healthcare professional before using progesterone cream to ensure the appropriate dosage and application method for individual needs.